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Prevention Pipeline

Grants to USA, Canada, and International Researchers and Clinicians
for Studies Related to the Prevention of Dementia and Cognitive Disease

Agency Type:

Foundation / Corporation

Funding Source:

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Alzheimer's Drug Discovery Foundation (ADDF)

LOI Date:

10/01/21

Deadline Date:

12/03/21 5:00 PM EST Receipt

Description:

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Grants to USA, Canada, and International clinicians and researchers working at universities, academic medical centers, nonprofits, and biotechnology companies for research on the prevention and treatment of Alzheimer's and related dementias. Applicants must submit a Letter of Intent prior to submitting a full application. Funding is intended to support studies of cognitive symptoms due to health conditions, comparative effectiveness research, and epidemiological studies that probe whether the use or choice of drugs alters the risk for dementia or cognitive decline.

The Prevention Beyond the Pipeline RFP supports:

  1. Studies of Cognitive Decline and Risk Reduction: Cognitive decline through aging and health conditions has been linked to an increased risk of dementia. The ADDF will consider funding programs to prevent and treat these conditions, including menopause-related cognitive symptoms, postoperative delirium, and postoperative cognitive decline, mild and/or repetitive traumatic brain injury, and chemotherapy-induced decline. Methods may include epidemiology or clinical trials. For clinical trial proposals, see the URL for Text, below,  under “Expectations and Evaluation”.
  2. Comparative Effectiveness Research: For many health conditions, physicians have a choice of clinically equivalent drugs. Some of these drugs are being investigated for repurposing to treat Alzheimer's or related dementias, due to potential disease-modifying properties that go beyond the treatment of their approved disease indication. The ADDF will consider funding research to generate an evidence base on whether choices in the routine clinical care of pre-existing conditions could protect from dementia. Priority will be given to the comparison of drugs that are otherwise clinically equivalent for the pre-existing condition. Methods may include randomized trials or epidemiology.
  3. Studies Leveraging the Consortium of Cohorts for Alzheimer's Prevention Action (CAPA): Epidemiological studies contribute unmatched information on whether the risk of dementia or cognitive decline may be influenced by long-term exposure to supplements or medications. However, high-powered studies are needed, ideally with dose, duration, and responder profiles, in order to translate epidemiological research into actionable interventions for testing. Through the CAPA Consortium, the ADDF funds collaborative analyses on dementia prevention using a minimum of five longitudinal cohorts, either harmonized or analyzed through parallel analysis of cohorts using a shared analysis script. More information can be found here: https://www.alzdiscovery.org/research-and-grants/funding-opportunities/capa-consortium

Type of therapy: Novel, repurposed, and repositioned drugs, as well as natural products and devices, will be considered. Therapeutic modalities of interest include small molecules, peptides, antibodies, gene therapies, antisense oligonucleotides, and stem cells. Other non-pharmacologic interventions, such as diet, meditation, and exercise, will not be considered.

Drug mechanisms or modes of action: Novel drug mechanisms and modes of action related to the biology of aging and other emerging therapeutic areas for dementia are considered a high priority. These include, but are not limited to:

  • Epigenetics
  • Inflammation
  • Mitochondria & metabolic function
  • Neuroprotection
  • Proteostasis
  • Synaptic activity and neurotransmitters
  • Vascular function
  • Other mechanisms and modes of action related to the biology of aging (e.g., senescent cells)
  • Other novel mechanisms or modes of action that are supported by compelling evidence demonstrated a rational biological connection to the disease process.

GrantWatch ID#:

GrantWatch ID#: 182777

Estimated Size of Grant:

Average Award: Up to $3,000,000 for clinical trials based on stage and scope of research. For studies requiring additional support, co-funding from other funding agencies or investors is encouraged

Term of Contract:

Average Duration:
- Multi-year
- Potential for follow-on funding

Additional Eligibility Criteria:

Funding is open to researchers and clinicians worldwide at:
- Academic medical centers and universities or nonprofits.
- Biotechnology companies. Funding is provided through mission-related investments that require return on investment based upon scientific and/or business milestones. Existing companies and new startups are both eligible.

Pre-Application Information:

Letters of Intent and Full Proposals must be received by 5:00 PM ET on the deadline date.

Upcoming Deadlines:
- Letter of Intent: February 5, 2021
- Invited Full Proposal: April 16, 2021

- Letter of Intent: May 28, 2021
- Invited Full Proposal: July 30, 2021

- Letter of Intent: October 1, 2021
- Invited Full Proposal: December 3, 2021

Applicants are encouraged to contact program staff to discuss proposed projects and receive initial feedback.

Application instructions: https://www.alzdiscovery.org/research-and-grants/funding-opportunities/application-instructions.

Funding Policies: https://www.alzdiscovery.org/research-and-grants/funding-opportunities/policies

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Apply online: https://addf.fluxx.io/

For scientific inquiries, please contact:
Yuko Hara, PhD, Director, Aging & Alzheimer's Prevention
yhara@alzdiscovery.org

For application submission inquiries, please contact:
Grants and Mission-Related Investments Team
grants@alzdiscovery.org

Alzheimer's Drug Discovery Foundation
57 West 57th Street, Suite 904
New York, NY 10019
info@alzdiscovery.org
212.901.8000

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta;   British Columbia;   Manitoba;   New Brunswick;   Newfoundland and Labrador;   Northwest Territories;   Nova Scotia;   Nunavut;   Ontario;   Prince Edward Island;   Quebec;   Saskatchewan;   Yukon;

Israel

International country outside of the USA, Israel and Canada.

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