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Target Advancement Program

Grants to USA, Canada, and International IHEs, Nonprofits,
and For-Profits for Research Related to Parkinson's Disease

Agency Type:

Foundation / Corporation

Funding Source:

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The Michael J. Fox Foundation (MJFF)

Conf. Date:

03/27/20

LOI Date:

05/14/20

Deadline Date:

09/02/20 5:00 PM ET

Description:

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Grants to USA, Canada, and International university labs, for-profit companies, and nonprofit research institutions for research projects that will lead to new developments in treating Parkinson's disease. Applicants must submit a pre-proposal prior to applying. Funding is intended to promote target and pathway validation studies within academic and industry laboratories to bridge the critical gap between basic biology and therapeutic development.

This program will support projects focused on validating targets and defining pathways implicated in PD pathological processes and/or symptomology. Applications should focus on studies that achieve one or more of the following goals:

  • Demonstrate pathological relevance of a target by studying its altered expression, distribution, or function in PD-relevant human tissues.
  • Demonstrate that modulation of the target or pathway in vivo in whole mammalian PD models using genetic or pharmacological manipulations yields outcomes predictive of clinical efficacy or relevance in human PD.
  • Elucidate target or pathway biology in disease-relevant models, including defining upstream/downstream modifiers and convergence of promising target pathways.
  • Replicate or further validate recently published, high-impact findings in PD biology.

Applicants may propose studies designed to assess PD targets in pre-clinical models, human cellular models, and human tissue and fluids. Investigators are encouraged to leverage existing tissue and biosample resources if possible. Studies requesting access to biosamples available through MJFF-sponsored biospecimen and cell line collections are eligible to apply to this initiative. In these cases, access to samples will be reviewed in parallel to funding requests by the committees overseeing the biospecimen collection(s) requested.

Please note that MJFF has made significant investments in the biology of high-priority targets, including alpha-synuclein, LRRK2, GBA and Parkin/PINK1. Proposals focusing on these targets will be considered on a case-by-case basis and carefully evaluated against the existing MJFF portfolio.

GrantWatch ID#:

GrantWatch ID#: 170931

Estimated Size of Grant:

Up to $200,000

Term of Contract:

Up to 18 months

Additional Eligibility Criteria:

Applications may be submitted by researchers or clinicians in:
- U.S. and non-U.S. biotechnology/pharmaceutical companies, or other publicly or privately held for-profit entities; and
- U.S. and non-U.S. public and private non-profit entities, such as universities, colleges, hospitals, laboratories, units of state and local governments and eligible agencies of the federal government.
- Post-doctoral fellows are eligible to apply as co-investigators with the designation of an administrative primary investigator who directs the laboratory in which the fellow will conduct research. The administrative PI will be responsible for assisting in providing all institutional documents required for the project and will be required to sign any award contract. Training or mentoring-only proposals will not be considered.

Pre-proposal Conference:

Applicants are invited to attend an informational webinar on March 27, 2020, at 12 p.m. ET to learn more about our Foundation's funding strategy and opportunities, and the application and review processes.

To register: https://www.michaeljfox.org/webinar/mjff-funding-opportunities-fall-2020

Pre-Application Information:

Deadlines:
- Pre-Proposals Due: Pre-Proposals Due: May 14, 2020 - 5 pm US ET
- Full Proposal Invitations: June 11, 2020
- Full Proposals Due (by invite only): September 2, 2020, 5 pm US ET
- Anticipated Award Announcement: November 2020
- Anticipated Funding: December 2020

Requested support should be commensurate with work proposed. These budgets include direct and indirect costs. For academic and for-profit institutions, no more than 15% or 10%, respectively, may go to indirect costs.

FAQs: https://www.michaeljfox.org/foundation/faq.html?navid=footer-faq

Guidelines: https://www.michaeljfox.org/news/application-guidelines

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Click here to apply online:
http://mjff.smartsimple.com/

The Michael J. Fox Foundation for Parkinson's Research
Grand Central Station
P.O. Box 4777
New York, NY 10163-4777
Toll-free: 1-800-708-7644
grants@michaeljfox.org

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta   British Columbia   Manitoba   New Brunswick   Newfoundland and Labrador   Northwest Territories   Nova Scotia   Nunavut   Ontario   Prince Edward Island   Quebec   Saskatchewan   Yukon

Israel

International country outside of the USA, Israel and Canada.

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